Sunday's Premiership Rugby Cup final between Sale and Harlequins at AJ Bell Stadium has been postponed.
The game was called off on Friday evening after an individual staff member from one of the clubs showed symptoms consistent with the coronavirus and went into isolation.
"We're incredibly sorry to all the people who will be disappointed," a Premiership Rugby statement said.
"However the welfare of fans, players and staff remains our first concern."
No new date has been set for the match.
The decision comes on a day of widespread sporting postponements worldwide.
- All elite British football has been suspended until 3 April.
- The London Marathon has been moved from 26 April to 4 October, with the Manchester and Brighton Marathons also postponed.
- Uefa has postponed next week's Champions League and Europa League fixtures.
- In rugby union, Saturday's Six Nations match between Wales and Scotland has been postponed.
- Cycling's Giro d'Italia, scheduled to start in Hungary in May, has been called off.
- England's Test cricket series in Sri Lanka has been cancelled.
- Golf's opening major of the year, the Masters, has been postponed.
- Formula 1 has called off the Vietnam Grand Prix on 5 April.
- Formula E is suspended for two months, affecting races in Paris, Seoul and Jakarta.
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Elsewhere in rugby union, Saturday's Six Nations game between Wales and Scotland has been called off, joining two already postponed fixtures - Italy v England and France v Ireland.
All of Sunday's Women's Six Nations fixtures have been cancelled, while the Pro14 competition and all French rugby union have been halted.
The Rugby Football Union issued a statement on Friday advising clubs to use the government's and Public Health England's guidance on the virus.
The government announced on Thursday that sporting events could continue to be staged.
As a result, rugby union games in England planned for this weekend are set to be played as usual.