Wales Women captain Carys Phillips won her 50th cap on Sunday in their 29-5 defeat to Spain in Madrid.
The Ospreys hooker, who turns 27 this month, earned her first cap as a replacement against Ireland in the 2013 Six Nations.
Spain led 12-0 at half-time through Olivia Fresneda and Beatriz Dominguez tries, with Lourdes Alameda, Anne Fernandez and Anna Puig then crossing.
Wales centre Alecs Donovan scored a late consolation for the visitors.
Six of Wales' starting line-up were making their debuts - wings Angharad de Smet and Caitlin Lewis, centre Megan Webb, prop Gwenllian Jenkins, lock Georgia Evans and flanker Abbie Fleming.
Two more uncapped - Ospreys Robyn Lock and Niamh Terry - were on the bench.
Wales next take on Ireland in Dublin on 10 November, with matches against Scotland, Crawshay's and Barbarians to follow.
Wales team v Spain (Estadio Nacional Computense, Madrid, Sunday, 3 November): Lauren Smyth; Angharad De Smet, Megan Webb, Kerin Lake, Caitlin Lewis; Robyn Wilkins, Keira Bevan; Gwenllian Jenkins, Carys Phillips, Amy Evans, Georgia Evans, Gwen Crabb, Abbie Fleming, Sioned Harries
Replacements: Kelsey Jones, Gwenllian Pyrs, Cerys Hale, Siwan Lillicrap, Robyn Lock, Niamh Terry, Elinor Snowsill, Alecs Donovan
Wales Women fixtures November 2019:
- Spain v Wales Women, Estadio Nacional Computense, Madrid, Sunday 3 November
- Ireland v Wales Women, The Bowl, UCD, Dublin, Sunday, 10 November
- Scotland v Wales Women, Glasgow, Sunday, 17 November
- Crawshay's v Wales Women, Eugene Cross Park, Ebbw Vale Saturday, 23 November
- Wales Women v Barbarians, Principality Stadium, Saturday 30 November