Gavin Henson made his Dragons debut at 10 in their 40-15 pre-season friendly defeat against Montpellier in Saint-Affriqueon.
The 35-year-old retuned to Wales this summer after six seasons in England.
Henson was named in the side in France while a different Dragons team will play Northampton at Franklin's Gardens on Saturday, 12 August (15:00 BST).
Wales wing Hallam Amos made his first appearance since suffering shoulder damage in November, 2016.
Amos missed the rest of last season after coming injured while playing for Wales against Australia.
The pre-season friendly against Montpellier was part of the Vaquerin Challenge and will be the first match for new head coach Bernard Jackman.
The former Ireland hooker travelling to Northampton for Saturday's game.
Dragons: C Meyer; A Hughes, S Beard, J Dixon, H Amos; G Henson, S Pretorius; T Davies, E Dee, L Fairbrother, M Screech, A Sweet, J Thomas, H Keddie, J Benjamin.
Replacements: R Buckley, P Price, L Brown, M Williams, N Cudd, C Davies, A O Brien, P Howard, A Hewitt, W Talbot Davies.