England Under-20 flanker Gus Jones scored four of England's 10 tries as they embarrassed their Wales counterparts in Newcastle.
Eight months after England U20 beat Wales 23-15 in the Junior World Championship final, the outcome was far more emphatic.
Jones went over twice as the hosts took a 38-0 lead at the break.
The one-way traffic continued after the break until the visitors were awarded a 78th-minute penalty try.
England full-back Howard Packman was sin-binned for an early tackle that prevented Afon Bagshaw.
Replacement Luke Price converted, but it was scant consolation for the Welsh youngsters as England's aspiring crop dominated.
Unbeaten France U20 remain on course for the 2014 title after their 18-13 win over Scotland U20.
England U20 lost 21-15 to France in their opener and bounced back with a 48-15 win over Scotland, before seeing off Ireland 33-9.
Wales U20 kicked off with a 26-9 win over Italy and beat Ireland 16-0, before a 16-10 defeat by unbeaten tournament leaders France.
England Under-20: Howard Packman (Northampton Saints); Zach Kibirige, (Newcastle Falcons), Nick Tompkins (Saracens), Harry Sloan (Harlequins), Henry Purdy (Leicester Tigers); Billy Burns (Gloucester Rugby), Henry Taylor (Loughborough University); Danny Hobbs-Awoyemi (Northampton Saints), Harry Thacker (Leicester Tigers), Scott Wilson (Newcastle Falcons), Maro Itoje (Saracens, capt), Tom Ellis (Bath Rugby), Ross Moriarty (Gloucester Rugby), Joel Conlon (Exeter Chiefs), Gus Jones (London Wasps).
Replacements: Tom Woolstencroft (Bath Rugby), Alex Lundberg (London Wasps), Paul Hill (Leeds Carnegie), Jonny Hill (Gloucester Rugby), Hayden Stringer (Saracens), Stuart Townsend (Exeter Chiefs), Sam Olver (Northampton Saints), Aaron Morris (Bedford Blues).
Wales Under-20: Afon Bagshaw (RGC); Tyler Morgan (Dragons), Steffan Hughes (Scarlets, capt), Jack Dixon (Dragons), Ashley Evans (Ospreys); Angus O'Brien (Dragons), Tom Williams (Blues); Nicky Smith (Ospreys), Ethan Lewis (Blues), Nicky Thomas (Ospreys), Scott Andrews (Dragons), Joe Davies (Dragons), Ben Roach (Blues), Ollie Griffiths (Dragons), James Benjamin (Dragons).
Replacements: Elliot Dee (Dragons), Luke Garrett (Dragons), Benjamin Leung (Scarlets), Rob Dudley-Jones (Ospreys), Will Boyde (Carmarthen), Luc Jones (Dragons), Luke Price (Ospreys), Joshua Adams (Scarlets).