Pro12 champions Ospreys start against Benetton Treviso
That game will be broadcast live on Scrum V on BBC Two Wales with a 1905 BST kick-off.
On the same night Newport Gwent Dragons host new Italian side Zebre and the next day Cardiff Bluesare at Connacht.
The Scarlets host Leinster in Y Clwb Rygbi's live broadcast on S4C on Saturday, 1 September.
The Blues' first competitive match at the permanent Arms Park home to which they have returned will be against Edinburgh on Friday, 7 September.
That clash will be Scrum V's featured live game on BBC Two Wales.
A day later, the Ospreys host Ulster at the Liberty Stadium, this time for Y Clwb Rygbi's audience on S4C.
The first Welsh derby of the season will be on Saturday, 15 September when the Dragons welcome the Blues to Rodney Parade for an 18:30 BST kick off on Y Clwb Rygbi.
The Christmas and New Year period is again set aside for all-Welsh clashes.
The Ospreys host the Dragons and the Blues visit the Scarlets on the weekend of 21-23 December.
On the weekend of 28-30 December, the Blues host the Dragons and the Ospreys welcome the Scarlets.
with the Liberty Stadium hosting Ospreys v Scarlets and the Blues facing the Dragons at the Arms Park.
The Pro12 play-off semi-finals are scheduled for the weekend of 10/11/12 May, with the grand final on Saturday 25 May.