Leaders Harlequins secured their place in the Premiership semi-final play-offs with a comfortable win over Wasps.
Tries from Ugo Monye and George Robson helped build a healthy lead before Christian Wade scored for the visitors.
But Quins had too much power for Wasps up front, with Chris Robshaw and Jordan Turner-Hall adding further tries.
Ross Filipo went over late on for Wasps while they had Billy Vunipola in the sin-bin, but they are only four points clear now of Newcastle at the bottom.
Wasps travel to Bath on Saturday after the Falcons host Saracens on Friday, before a likely relegation decider between the two bottom clubs when Wasps host Newcastle on Saturday 5 May, the final day of the regular season.
Quins, meanwhile, are six points clear at the top and will claim a home semi-final if they beat second-place Leicester at The Stoop next Saturday, before completing their regular-season fixtures with a trip to Sale on 5 May.
Harlequins director of rugby Conor O'Shea:
"Is next week (against Leicester) the be all and end all? No it's not, but it'll be a great contest because I'd like to reflect for the second time in play-off history - we're now in it.
"That's one thing ticked we now want to get a home tie. There's a lot of rugby to play but I was happy with the ambition and the physicality of some of our play."
Wasps director of rugby Dai Young:
"It doesn't get much tougher than this week," he said. "When people are starting to worry about whether they've got a job in four or five weeks' time - surely it doesn't get any tougher.
"Obviously it's a bit more serious than we all thought initially. You have to put that to the back of your mind if you can, I'd be a liar to say that it's easy because it's not but we have to go out there and do a job for each other basically.
"Our side of the bargain is to make sure we've got Premiership rugby, we've got to do the best that we can because make no bones about it we're going to be a far more attractive team playing Premiership rugby.
"We've got to dust ourselves off now and go down to Bath next week and obviously try and get that win down there."
Harlequins: Brown; Monye, Lowe, Turner-Hall, Smith; Clegg, Care; Marler, Buchanan, Johnston; Kohn, Robson; Fa'asavalu, Robshaw (capt), Easter.
Replacements: Croall, Lambert, Collier, Vallejos, Guest, Dickson, Urdapilleta, Chisholm.
Wasps: Haughton; Wade, Daly, Davis, Varndell; N Robinson, Davies; Payne, Lindsay, Broster; Cannon, Birkett (capt); Launchbury, Poff, Jones.
Replacements: Korshunov, Taulafo, McIntyre, Filipo, Vunipola, L Robinson, Mayor, Wallace.