England have brought Thomas Waldrom and Matt Banahan into their squad ahead of Saturday's Six Nations opener against Scotland at Murrayfield.
Leicester forward Waldrom and Bath back Banahan replace injured Henry Trinder (ankle) and Luke Narraway (calf).
Waldrom and Banahan played for the Saxons in Saturday's 23-17 win over second-string rivals Irish Wolfhounds.
Waldrom, an injury replacement at the World Cup, scored a second-half try, while Bath's Banahan was on the wing.
England's interim coach Stuart Lancaster will also be without Waldrom's Leicester team-mates Toby Flood (knee) and Manu Tuilagi (calf), as well as Northampton pair Courtney Lawes (knee) and Tom Wood (foot) for the annual Calcutta Cup clash.