Harlequins wing Ugo Monye will have a scan on damaged knee ligaments on Monday which could determine his hopes of making England's World Cup squad.
The 2009 British & Irish Lion scored England's second try in their 38-32 defeat by the Barbarians at Twickenham.
But he was forced off early in the second half with a medial collateral ligament strain in his knee.
"He will be assessed in the morning but it doesn't look too bad," said England Saxons coach Stuart Lancaster.
Monye is contesting one of the final wing spots in England's World Cup squad along with David Strettle and James Simpson-Daniel, behind Test incumbents Chris Ashton and Mark Cueto.
He will hope that he has suffered only a grade one strain, which can take anything between two and 10 weeks to heal.
Anything higher could see his World Cup hopes at an end, with Martin Johnson set to unveil his 30-man squad in 12 weeks, after the first two of three warm-up Tests in August.
Lancaster, who took charge of England for the Barbarians fixture, also reported that centre Matt Banahan - almost certain to travel to New Zealand - suffered a soft tissue shin injury on Sunday.
Monye's Harlequins team-mate Joe Marler, meanwhile, suffered a mild concussion that saw him stretchered off the second half.
"It wasn't spinal; that is the protocol to get him off the field," said Lancaster, who will unveil a 26-man Saxons squad on Monday for the forthcoming Churchill Cup.
The selection is likely to include many of those on duty on Sunday as well as Saracens prop Matt Stevens, who capped his return from a two-year drugs ban by collecting a Premiership winners' medal on Saturday.
England blew a 17-point lead as the Barbarians overturned a 24-7 deficit to lead 31-24 before one of five debutants, Exeter flanker Tom Johnson, put the hosts back in front with a try eight minutes from time.
But a vastly experienced Baa-Baas side conjured a last-minute try for wing Tim Visser to steal victory.
"I was proud of our performance in terms of the inexperience of our side in relation to theirs," added Lancaster. "We put ourselves in a position at 32-31 where we could have won it.
"I guess at the end their experience and quality told.
"As a lead into the Churchill Cup and for players to get the experience of playing at Twickenham and benchmark themselves against World Cup players, it is valuable."
Captain Luke Narraway was one player who impressed, having a hand in first-half tries scored by Henry Trinder and James Simpson-Daniel, and could earn a place in a 40 to 44-man World Cup training squad.
"I tried to play to the best of my ability," said Gloucester number eight Narraway. "If it is enough to make the World Cup training squad, I'll be happy.
"This was a massive opportunity because some of those guys were going out there for the first time against world-class opposition."