Holders Leeds Rhinos have been drawn against Hull FC in the quarter-finals of the Challenge Cup.
Super League leaders Leeds travel to the KC Stadium next month, while Hull KR host Catalans Dragons after the French side battled past Featherstone.
Championship pacesetters Leigh fought back to upset top-flight side Wakefield and set up last eight meeting with another Super League side, Warrington.
St Helens face Widnes after the Vikings overcame Batley 26-22 on Sunday.
Quarter-final matches will be played between 25 and 28 June.
Leigh extended their winning run to 25 matches by beating Wakefield, their second Super League opponent in as many rounds, to reach the last eight.
Hull KR stunned 19-time Challenge Cup winners Wigan to progress to the quarter-finals, while Leeds and defending Super League champions St Helens eased through.
Challenge Cup quarter-final draw
Hull KR v Catalans
Warrington v Leigh
Hull FC v Leeds
St Helens v Widnes