Catalan Dragons full-back Cyril Stacul is out for at least six weeks after breaking his ankle in Sunday's 30-16 Challenge Cup defeat at Huddersfield.
The 26-year-old is the latest in a series of casualties for the Dragons.
Prop Remi Casty and centre Ben Farrar are still four to six weeks away from a return with knee injuries sustained in the Cup fourth round win at Leigh.
And Steve Menzies, Cyrille Gossard, Clint Greenshields and Vincent Duport all missed the Huddersfield game.
Australian back-row Menzies could make a return in Friday's trip to St Helens.
And full-back Greenshields, who has been out since the beginning of April with a dislocated elbow, is also set to make an imminent return.
But second row Gossard could still be missing for a further fortnight.
French international Stacul, who has been at the club since joining from Villeneuve in 2007, has scored five tries in 14 appearances in this year's Super League.
His absence will be a timely blow as the Dragons prepare to face three of the top four Super League sides in their next four fixtures.
Catalans currently lie seventh in the table, five points behind league leaders Warrington.