Northern Ireland will not face strikers Andrey Arshavin or Roman Pavlyuchenko in their opening World Cup qualifier against Russia on 7 September.
New coach Fabio Capello has left both out of his squad, along with Reading frontman Pavel Pogrebnyak.
Arshavin rejoined his former club Zenit St Petersburg on loan from Arsenal last February and was Russia's captain at the Euro 2012 tournament.
He played as a substitute in the recent friendly draw with the Ivory Coast.
Former Spurs forward Pavlyuchenko started that 15 August game which was Capello's first match in charge after replacing Dick Advocaat.
Arshavin, 31, has scored 17 goals for Russia in 74 appearances since making his debut in 2002.
Also out of the Northern Ireland match are winger Yuri Zhirkov and 36-year-old midfielder Sergei Semak who are injured.
Russia are away to Israel four days after playing Michael O'Neill's side in Moscow's Lokomotiv Stadium.
Russia squad - goalkeepers: Igor Akinfeyev (CSKA Moscow), Anton Shunin (Dynamo Moscow), Vladimir Gabulov (Anzhi Makhachkala).
Defenders: Alexander Anyukov (Zenit St Petersburg), Alexei Berezutsky (CSKA Moscow), Vasily Berezutsky (CSKA Moscow), Sergei Ignashevich (CSKA Moscow), Georgy Shchennikov (CSKA Moscow), Taras Burlak (Lokomotiv Moscow), Andrei Yeshchenko (Lokomotiv Moscow).
Midfielders: Igor Denisov (Zenit St Petersburg), Roman Shirokov (Zenit St Petersburg), Konstantin Zyryanov (Zenit St Petersburg), Vladimir Bystrov (Zenit St Petersburg), Viktor Faizulin (Zenit St Petersburg), Alan Dzagoyev (CSKA Moscow), Denis Glushakov (Lokomotiv Moscow), Magomed Ozdoyev (Lokomotiv Moscow), Alexander Samedov (Lokomotiv Moscow), Dmitry Kombarov (Spartak Moscow), Diniyar Bilyaletdinov (Spartak Moscow).
Forwards: Alexander Kerzhakov (Zenit St Petersburg), Artem Dzyuba (Spartak Moscow), Alexander Kokorin (Dynamo Moscow).