Enda McGinley has become the fifth Tyrone player to retire from inter-county football in the past two months.
The 31-year-old Errigal Ciaran midfielder was in the Red Hands teams which won All-Ireland senior titles in 2003, 2005 and 2008.
The 2008 All Star, who has struggled with injuries in recent years, also won All-Ireland minor and U21 medals.
McGinley joins Brian Dooher, Brian McGuigan, Philip Jordan and Ciaran Gourley in quitting the Red Hands.
McGinley's trophy haul also includes two Ulster crowns and a national league success.
Gourley played at corner back on the first Red Hands side to win the Sam Maguire Cup in 2003.
He missed the 2005 triumph because of a cruciate ligament injury, but returned to play a part in Tyrone's third All-Ireland success in '08.
McGuigan and Jordan also retired earlier this month while former captain Dooher stepped down in September.