Celtic Dragons completed the season double over Strathclyde Sirens in front of a sell out crowd at Cardiff Metropolitan University.
In a feisty affair, the home team took a 29-23 half-time lead.
Sirens attempted to stage a comeback but the Dragons defence made some vital interceptions and went on to win the the match 59-49.
The win is Dragons' fifth of the Superleague season, their best win rate since 2014.
Dragons head coach Tania Hoffman told BBC Sport Wales:
"I'm very happy with that win. The girls ground that win out in what was a very physical game.
"We've still got to learn that when we take a lead we have to keep going, but overall I thought both our defence and attack did very well."