A slow start was to prove costly as the Celtic Dragons lost 55-52 to Team Northumbria in their first away match of the Superleague season.
The Dragons trailed 17-5 at the end of the first quarter and the deficit proved too much to overcome.
Dragons coach Melissa Hyndman described the defeat as a "terrible performance" following their opening win against Team Bath.
The Welsh side next face Hertfordshire Mavericks, who also have one win from two games, in Cardiff on Thursday.
Celtic Dragons squad: Suzy Drane, Sara Hale (joint captains) Jamilla Abbott, Lottysha Cato, Crystal Ann George, Nichola James, Kyra Jones, Chelsea Lewis, Sophie Morgan, Cara Lea Moseley, Rosie Pretorius, Emma Thomas, Brooke Williams, Stephanie Williams
Superleague teams: Hertfordshire Mavericks (champions), Surrey Storm (runners-up), Loughborough Lightning, Northern Thunder, Team Bath, Team Northumbria, Yorkshire Jets, Celtic Dragons