England's Owen Farrell returns from injury for Saracens after missing their third win in three at Northampton.
Scrum-half Richard Wigglesworth will overtake former captain Steve Borthwick as club record Premiership appearance-maker as he steps out for game 266.
Prop Val Rapava Ruskin is the only change among the replacements.
Jamie George will make his 200th appearance for Saracens, who feature five changes including Farrell's return and a first start of the season for second row George Kruis as Maro Itoje switches to flanker.
Saracens: Williams; Strettle, Tompkins, Barritt (capt), Maitland; Farrell, Wigglesworth; M Vunipola, George, Koch, Kruis, Skelton, Itoje, Rhodes, Earl.
Replacements: Tolofua, Barrington, Lamositele, Isiekwe, Burger, Spencer, Lozowski, Goode.
Gloucester: Woodward; Sharples, Trinder, Twelvetrees, Banahan; Cipriani, Braley; Hohneck, Marais, Balmain, Slater (capt), Grobler, Polledri, Ludlow, Ackermann.
Replacements: Hanson, Rapava Ruskin, Knight, Clarke, Morgan, Vellacott, Atkinson, Hudson.
Referee: Christophe Ridley (RFU).