Ospreys: D Evans; K Giles, K Fonotia, O Watkin, C Allen; D Biggar, R Webb; N Smith, S Otten, D Arhip, B Davies, A Wyn Jones (capt), D Lydiate, J Tipuric, D Baker.
Replacements: S Parry, P James, M Fia, L Ashley, O Cracknell, T Habberfield, S Davies, J Hook.
Clermont Auvergne: S Spedding; D Strettle, D Penaud, R Lamerat, A Raka; C Lopez, M Parra (capt); R Chaume, B Kayser, R Slimani, P Jedrasiak, S Vahaamahina, J Cancoriet, A Lapandry, F Lee
Replacements: Y Beheregaray, E Falgoux, A Jarvis, S Timani, P Yato, G Laidlaw, P Fernandez, P Betham.
Ospreys scrum-half Rhys Webb has recovered from a calf problem to start Sunday's Champions Cup opener against Clermont Auvergne in Swansea.
Justin Tipuric and Dan Baker return to the back-row as coach Steve Tandy makes five changes from the 18-19 loss to Scarlets in the Pro14.
Keelan Giles, Dmitri Arhip and Owen Watkin start, with James Hook and Sam Davies on the bench.
Clermont are without backs Nick Abendanon and Wesley Fofana.
But Alivereti Raka returns after a heel injury, while Rabah Slimani, Benjamin Kayser and Raphael Chaume start in an all-changed front row from the win over Toulouse.
France scrum-half Morgan Parra will make his 200th appearance for Clermont.