England international fly-half Freddie Burns makes his first start for home-town club Bath, who make four changes for the visit of Worcester.
Inside centre Ben Tapuai also comes in to the backline, while Anthony Perenise and Elliott Stooke start in the pack.
Bottom club Warriors make two changes to the side beaten 25-3 at home by Saracens at Sixways last week.
Dean Hammond comes in on the wing for Perry Humphreys, while Sam Lewis replaces Alafoti Faosiliva at flanker.
New Warriors signing Jono Lance could make his debut from the bench, while centre Wynand Olivier is back in the 23 after recovering from a hamstring injury.
This is winless Worcester's first game since director of rugby Gary Gold, formerly the boss at Bath, announced that he is to leave at the end of the season to coach the USA national team.
Bath: Watson; Rokoduguni, Joseph, Tapuai, Brew; Burns, Cook; Obano, Walker, Perenise, Ewels (capt), Stooke, Mercer, Underhill, Faletau.
Replacements: Dunn, Auterac, Thomas, Phillips, Douglas, Fotuali'i, Lewis, Clark.
Worcester: Pennell; Adams, Willison, Te'o, Hammond; Shillcock, Arr; Bower, Singleton, Alo, O'Callaghan (capt), Spencer, Denton, Lewis, Van Velze.
Replacements: Taufete'e, Waller, Milasinovich, Scotland-Williamson, Faosiliva, Stringer, Lance, Olivier.