Garry Breen is a late withdrawal from the Cliftonville side after getting injured in the pre-match warm-up. Shane Grimes comes into the starting team and Aaron Donnelly takes his place on the bench.
Joe Gormley went close with a header but Ballymena reduced to 10 men on 31 minutes when Kevin Braniff was sent off for two yellow card offences.
In the second half, Joe Gormley has fired inches wide, Jamie Harney headed off-target while Rory Donnelly has squandered two glorious chances from close range.
Jay Donnelly eventually puts the Reds in front with a composed finish in the 67th minute and the forward adds his second on 81.
Joe Gormley side-foots in his side's third four minutes from time and then curls a shot into the top corner to make i 4-0.