Min gained revenge for his 2018 defeat with a 20-length win over Politologue in the JLT Melling Chase at Aintree.
The eight-year-old, who went off a 2-1 favourite, romped clear of his rivals in what trainer Willie Mullins called "a career-best performance".
Politologue, who beat Min by a neck in last year's staging, was second, with Waiting Patiently third.
Earlier Lostintranslation won the Mildway Novices' Chase for trainer Colin Tizzard.
Forest Des Aigles was put down after breaking a leg while running on the flat in the Topham Handicap Chase, with Crucial Role also a fatality after coming down in the Mildmay Novices' Chase.
Min's victory, which came after a below-par run at Cheltenham's Champion Chase, was a boost for owner Rich Ricci, who saw Faugheen pulled out of Thursday's Aintree Hurdle with an irregular heartbeat.
"I didn't think he jumped as well at Cheltenham as he could but he attacked the hurdles today and was a lot happier," said winning jockey Ruby Walsh of Min.
"He was doing plenty and was lively in my hands, but that is him.
"He is a very honest horse. That was a very, very good performance."
There was another victory for Mullins in the Topham where Cadmium won under Paul Townend.
It was a more disappointing day for rival trainer Paul Nicholls who saw Mildmay Novices' hope Topofthegame beaten, along with Politologue.