Michael Hoey and Gareth Maybin both missed the cut at the Wales Open at Celtic Manor.
Hoey was unable to undo the damage of his opening 74 as his 71 kept him on him overnight position of three over which proved two shots too many.
Maybin had fired a disappointing opening 77 and finished on four over despite a 69 on Friday.
Shane Lowry leads on nine under after a 65, which left him a shot ahead of Joost Luiten and Nicolas Colsaerts.
Ballyclare golfer Maybin posted a round which included five birdies and three bogeys.
Maybin began the tournament just one place outside a position in the top 110 in the Race to Dubai rankings which would secure his European Tour card.
Hoey's round of two bogeys and two birdies was a steadier affair than his opening 74 which had included a triple bogey and two double bogeys.
However, it still represented another disappointing week for Hoey who has missed the cut in four of his last five events after producing steady form during the first half of the season.
Simon Thornton is sharing 22nd place on two under after firing a 69 on Friday while Damien McGrane was the only other Irish player to make the cut after his 72 left him on the survival mark of one over.
Kevin Phelan exited on seven over after a 76 with David Higgins  on eight over and Peter Lawrie  a further shot back.