The 31st Premier League season begins earlier than usual - Crystal Palace face Arsenal on Friday - as football tries to fit in a winter World Cup.
What is new this season, who are the new faces and how does the winter break work?
BBC Sport explains all...
The biggest change is that each team can make five substitutions a game, up from three.
The Premier League brought the rule in for the remainder of the 2019-20 season when football returned after the first Covid lockdown in 2020.
While most of Europe's other leagues - and Uefa competitions - kept five subs, English football went back to three.
Now five substitutions will be allowed from a bench of nine players. Teams have three opportunities to use their five subs - plus the option to make them at half-time - after which no more subs can be made.
Players will only take the knee before selected games now, previously the anti-racism gesture featured before every match.
Premier League clubs have been advised not to stop games for a medical emergency in the stands unless absolutely necessary.
Assistant referees have been instructed to only delay raising their flag for an obvious offside when there is an immediate chance of a goal and tight calls.
There will be enhanced searches outside stadiums and the use of sniffer dogs to cut down on flares and smoke bombs in games.
In another change, the Premier League will bring in in a multi-ball system to reduce delays when the ball is out of play.
There will be 10 balls in total - the match ball, one with the fourth official and eight around the pitch on cones next to a 'ball assistant'.
There are also provisions for games being postponed because of missing players, although the Premier League will assess each team's request on a case-by-case basis.
"Approval will only be granted where the impact of player unavailability on a club's squad is truly exceptional and where the club concerned has taken all reasonable steps to avoid the necessity to make the application," it says.
There is also a new ball...
- The Premier League is back - get the latest on your team
- Up for debate: Five games, five arguments - you decide who wins
Nottingham Forest are back in the Premier League for the first time in 23 years, since being relegated in 1998-99.
It took them 8,414 days and 1,069 league and play-off games to get back, beating Huddersfield 1-0 at Wembley in May. No team has spent longer in the Championship before returning to the Premier League.
The other two teams coming up have been in the top flight more recently.
Scott Parker and Fulham, who were relegated in 2020-21, are back in the Premier League now - but not together.
Fulham, under Marco Silva, made it five seasons in a row of bouncing between the Championship and Premier League when they secured promotion as champions.
Parker left Craven Cottage for Bournemouth last June and took the Cherries, who were in the Premier League until 2020, up in second place.
One familiar team will be missing, though - it will be the first Premier League season without Burnley since 2015-16. Norwich and Watford went down after only one campaign.
- A season like no other, but some things won't change - Shearer
- Premier League predictions: Who will be champions?
Erik ten Hag becomes the eighth person to manage Manchester United - including caretakers and interim bosses - since Alex Ferguson's retirement in 2013.
The 52-year-old led Ajax to two Dutch doubles and a third Eredivisie title in his four and a half years in Amsterdam.
United will hope he can help them get back into the Champions League and challenge for a first trophy since 2017.
The other new manager is Welshman Steve Cooper at Nottingham Forest.
The 42-year-old, who never played in England, managed England Under-16s and 17s before a two-year spell as Swansea boss.
He took charge at Forest in September, when they were bottom of the table and in the midst of their worst start to a season since 1913, and led them to promotion via the play-offs.
Parker and Silva have managed in the Premier League before, while Ten Hag was the only summer managerial change.
- Watch The Football News Show on BBC iPlayer
- Bumper Premier League quiz page
- Chris Sutton's Premier League predictions for opening weekend
There have been several big Premier League signings this summer, but all eyes will be on Manchester City striker Erling Haaland.
The £51m signing from Borussia Dortmund has scored more than 130 goals in club football and another 20 for Norway. He has just turned 22.
Another big deal saw Liverpool replace Sadio Mane, who left for Bayern Munich, with Benfica striker Darwin Nunez for £64m.
Tottenham signed Everton striker Richarlison for £60m, Manchester City sold striker Gabriel Jesus and defender Oleksandr Zinchenko for a combined £75m to Arsenal and Raheem Sterling to Chelsea for £50m.
City signed Leeds midfielder Kalvin Phillips for £45m, Manchester United brought in Ajax defender Lisandro Martinez and Chelsea recruited Napoli defender Kalidou Koulibaly.
West Ham spent more than £60m on Rennes defender Nayef Aguerd and Sassuolo striker Gianluca Scamacca.
Among the big names who left the Premier League are Alexandre Lacazette, Paul Pogba, Mane, Romelu Lukaku, Antonio Rudiger, Andreas Christensen and Raphinha.
- Watch The Football News Show on BBC iPlayer
- Who will finish where in the Premier League in 2022-23?
- Opening weekend: Predict the starting XI for your team
New winter break
In a first for English football, there will be six weeks without a Premier League game this winter - as a result of the Qatar World Cup being moved to November and December.
There will be no Premier League football between 13 November and 26 December.
Teams are also expected to have more time between their Christmas games, although there will only be two days without matches between 26 December and 5 January.
The season starts a week earlier than last term - Friday 5 August - and ends a week later - Sunday 28 May - to fit that break in.
- Our coverage of your Premier League club is bigger and better than ever before - follow your team and sign up for notifications in the BBC Sport app to make sure you never miss a moment