Liverpool captain Jordan Henderson added to the club's defensive problems after going off injured in the first half of Saturday's Merseyside derby.
He was replaced by the inexperienced Nathaniel Phillips after appearing to sustain a muscle injury.
The England midfielder, 30, was playing in defence with several of the club's first-choice centre-backs injured.
"It's not good. It's how it is," said Reds boss Jurgen Klopp after the 2-0 defeat by Everton.
Henderson joins Virgil van Dijk, Joel Matip, Joe Gomez and Fabinho on Liverpool's injury list.
Matip has been ruled out for the remainder of the season while both Gomez and Van Dijk are also long-term absentees.
'We have to keep going'
The loss of Henderson added to the disappointment of the derby defeat, as Everton won at Anfield for the first time in 22 years.
Liverpool have now lost four successive home matches for the first time since 1923, with the defending champions enduring their worst run of form of the season.
The Reds have won just two of their last 11 league games, and Klopp said: "There is no alternative but to keep going.
"You concede which is not cool, lose Jordan Henderson which is not cool and I feel the boys dealt with it quite well, could they deal with it better? Maybe. We will keep going."
'Now everyone wants to play against Liverpool'
Former Reds captain Graeme Souness says the current side is "a shadow of the team" Liverpool have been in the last few years and described them as "an easy touch".
"As a Liverpool supporter I'm deeply disappointed with my team," the Sky Sports pundit said.
"It didn't look like they had any energy or real fight, or real aggression about them, and the best team got the points.
"I think it is a shadow of the team Liverpool have been for three years. Now everyone wants to play against them, they are an easy touch. That hurts me, to say that."
- Eating With My Ex: Celebrity Specials: Famous exes come face to face to answer some awkward questions
- Line of Duty series 1-5: You won't be able to stop watching this nail-biting show