Match ends, Brighton and Hove Albion 2, Blackpool 1.
Yves Bissouma netted a stunning goal as Premier League Brighton edged out League One side Blackpool to reach the fifth round of the FA Cup.
Bissouma's near 30-yard effort found the top corner in the 27th minute before Luke Garbutt's cross was stabbed home by Blackpool's Gary Madine.
Brighton deservedly retook the lead as Alexis Mac Allister's shot deflected in off Steven Alzate after 58 minutes.
The hosts face the winners of Brentford v Leicester in the next round.
The Bees take on in-form Leicester in the fourth round on Sunday at 14:30 GMT.
- Follow live text commentary of Saturday's fourth-round ties
- Lawro's FA Cup predictions v Radio 1 DJ Jordan North
Visitors Blackpool, who had a Covid-19 outbreak in the squad, made seven changes to the side that beat West Brom on penalties in the last round.
The Seagulls - who had progressed from 13 of their past 15 FA Cup ties against sides from a lower division coming into this tie - started the sharper at the Amex Stadium, with centre-backs Lewis Dunk and Adam Webster both going close from corners.
They were deservedly ahead midway through the first period courtesy of Bissouma, before a defensive lapse saw Blackpool's Madine beat his marker and level matters just before the half-time whistle.
Mac Allister had a curling shot well-saved by Tangerines keeper Chris Maxwell in the 55th minute.
But the Welsh stopper was cruelly wrong-footed moments later as Alzate inadvertently netted his first goal for Brighton.
Maxwell denied Mupay and Davy Propper in the closing stages as Brighton reached the fifth round for the third time in the past four seasons.
'I was nearly frustrated when he shot' - reaction
Brighton manager Graham Potter:
"We were getting a bit frustrated with Bissouma because he had a couple of shots before that that were scuffed along the floor.
"And, when he shot, I was nearly close to getting frustrated again and then you see it fly in the top corner and it's hard to argue with that.
"I thought we controlled the game but while it's only by one goal, anything can happen, especially in this competition.
"Credit to Blackpool, they were organised, and it's nice for us to go through."
Blackpool boss Neil Critchley:
"We had a plan for this game but, with some of those players missing, it did create a little bit of a dilemma.
"We decided to go with the plan we had and I thought the players carried that out extremely well.
"If it wasn't for a wonder strike and a deflected shot then they didn't create too many clear opportunities.
"We were always in the game, we did everything we could physically but we just weren't quite good enough to create that opportunity near the end that might have got us into extra-time."
Madine the FA Cup's top scorer - the stats
- Yves Bissouma has scored four goals in all competitions for Brighton, with all four coming from outside the box.
- Gary Madine's equaliser for Blackpool was his fourth goal in the FA Cup this season, making him the top scorer in the competition so far this campaign.
- Brighton have now progressed from 14 of their last 16 FA Cup ties against sides from a lower division.
- 17AlzateSubstituted forMarchat 61'minutes
- 22TauSubstituted forMaupayat 61'minutes
- 10Mac AllisterSubstituted forTrossardat 61'minutes
- 29ZeqiriSubstituted forGroßat 76'minutes
- 4ThornileySubstituted forKaikaiat 77'minutes
- 17Virtue-ThickSubstituted forLubalaat 77'minutes
- 14MadineSubstituted forSarkicat 77'minutes
- 9YatesSubstituted forSimmsat 66'minutes
- Darren England
- Shots on Target
Second Half ends, Brighton and Hove Albion 2, Blackpool 1.
Lewis Dunk (Brighton and Hove Albion) wins a free kick in the attacking half.
Foul by Ellis Simms (Blackpool).
Foul by Dan Burn (Brighton and Hove Albion).
Jordan Lawrence-Gabriel (Blackpool) wins a free kick in the defensive half.
Attempt missed. Yves Bissouma (Brighton and Hove Albion) right footed shot from outside the box is too high. Assisted by Leandro Trossard.
Attempt saved. Davy Pröpper (Brighton and Hove Albion) header from the centre of the box is saved in the bottom left corner. Assisted by Solly March with a cross.
Attempt missed. Pascal Groß (Brighton and Hove Albion) right footed shot from very close range misses to the left. Assisted by Leandro Trossard with a cross.
Attempt missed. Solly March (Brighton and Hove Albion) right footed shot from the left side of the box is close, but misses to the right. Assisted by Leandro Trossard.
Offside, Brighton and Hove Albion. Pascal Groß tries a through ball, but Dan Burn is caught offside.
Yves Bissouma (Brighton and Hove Albion) wins a free kick in the defensive half.
Foul by Oliver Sarkic (Blackpool).
Foul by Lewis Dunk (Brighton and Hove Albion).
Ellis Simms (Blackpool) wins a free kick in the defensive half.
Attempt missed. Pascal Groß (Brighton and Hove Albion) left footed shot from the left side of the box is just a bit too high. Assisted by Solly March.
Attempt saved. Neal Maupay (Brighton and Hove Albion) left footed shot from the centre of the box is saved in the top centre of the goal. Assisted by Leandro Trossard with a cross.
Foul by Joël Veltman (Brighton and Hove Albion).
Bez Lubala (Blackpool) wins a free kick on the left wing.
Substitution, Blackpool. Sullay Kaikai replaces Jordan Thorniley.