Wales will face Belgium, the Czech Republic, Belarus and Estonia in 2022 World Cup qualifying Group E.
Wales begin and end their campaign with games against Belgium, the current world number one in the Fifa rankings.
The two nations will meet for the first time since Wales' victory in the quarter-finals of Euro 2016.
Wales are ranked 19th and the Czechs are 48th but will be tricky opponents, while the rest of the five-strong pool has a distinctly Eastern European feel.
Europe will send 13 countries to the finals in Qatar, which will be held from 21 November to 18 December 2022, 10 of which will be the group winners.
The 10 group runners-up will go through to the play-offs, along with the two best Nations League group winners who do not finish in the top two of their World Cup qualifying group.
The 12 play-off teams will be drawn into three separate play-off paths, each of which will comprise semi-finals and final, with the three winners heading to Qatar.
Wales' World Cup qualification fixtures:
- Belgium v Wales, Wednesday, 24 March
- Wales v Czech Republic, Tuesday, 30 March
- Belarus v Wales, Sunday, 5 September
- Wales v Estonia, Wednesday, 8 September
- Czech Republic v Wales, Friday, 8 October
- Estonia v Wales, Monday, 11 October
- Wales v Belarus, Saturday, 13 November
- Wales v Belgium, Tuesday, 16 November
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