Shrewsbury Town's on-loan Wolverhampton Wanderers goalkeeper Matija Sarkic and defender Ryan Sears could be out for up to three months with injury.
Montenegro international Sarkic, 23, who has played four times since joining Town on a season-long loan, may be out for up to three months following a hamstring injury picked up at Plymouth.
Sears hurt his ankle in the EFL Trophy win over Newcastle United Under-21s.
The 21-year-old Welsh defender is likely to be out for 10 to 12 weeks.
"This is one of those things that gets thrown at you in football," said manager Sam Ricketts. "You can't do anything about it.
"It causes a few headaches and a few things to sort out. Ultimately, the big disappointment is for the players."