Sevilla claimed the Europa League last season - but there is little time to rest on their success.
The Europa League draw is on Friday (12:00 BST), after the final qualifiers were played on Thursday night.
Here is everything you need to know.
How does the draw work?
The 48 teams will be split into four pots - determined by their club coefficient rankings - to form 12 groups.
In some cases, where associations have two or more teams involved in the draw, they may be paired so that they play with different kick-off times for the benefit of TV audiences.
Once again, no team can be drawn against another from their own association, so English sides Leicester City and Arsenal will avoid facing each other.
Who will be in the draw?
There are 18 automatic qualifiers - Villarreal, Real Sociedad, Leicester, Arsenal, Napoli, Roma, Bayer Leverkusen, Hoffenheim, Lille, Nice, Braga, Feyenoord, Wolfsburg, CSKA Moscow, Royal Antwerp, Zorya Luhansk, Sivasspor, Sparta Prague - along with Benfica, AZ Alkmaar and Rapid Vienna who were eliminated from the Champions League third qualifying round.
They will be joined by the 21 winners from the play-off round and six teams who are eliminated from the Champions League play-offs.
What is the British interest?
Leicester were beaten to a top-four place on final day of the Premier League season to finish fifth and end up in the Europa League. Mikel Arteta steered Arsenal to victory in the FA Cup final over Chelsea to claim a spot in the competition.
North London rivals Tottenham beat Maccabi Haifa at Tottenham Hotspur Stadium in the play-off round on Thursday for a spot in the draw.
Two Scottish Premiership sides are also in the draw. Celtic beat Bosnian side FK Sarajevo while Rangers progressed against Turkish giants Galatasaray.
When are the match days?
Matchday one: 22 October
Matchday two: 29 October
Matchday three: 5 November
Matchday four: 26 November
Matchday five: 3 December
Matchday six: 10 December
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