Hamilton head coach Brian Rice says clubs should expect more disruption after Lee Hodson was forced to isolate after housemate Jak Alnwick, of St Mirren, tested positive for Covid-19.
Hodson, the 28-year-old Accies defender, has initially tested negative but must isolate for 14 days.
St Mirren confirmed on Thursday that goalkeeper Alnwick was found to have Covid-19 after testing.
"It's just unfortunate, it's the world we live in at the minute," Rice said.
"It's not the first time and it won't be the last time over the coming months."
Rice revealed Hodson was contacted by the St Mirren player immediately after his test result and told the club on Tuesday morning.
The rest of Hamilton's squad have tested negative, with Rice "hoping it's an isolated case".
Hodson will miss away games against Livingston and Kilmarnock.
"It's very frustrating because you pick your team and you're working on a couple of things and something outwith the football changes the circumstances," Rice added.