Match ends, Sevilla 2, Roma 0.
Five-time winners Sevilla dominated against Roma as the Spanish side progressed to the Europa League quarter-finals.
They will face Premier League side Wolves after they beat Greek champions Olympiakos in the last eight.
On-loan Real Madrid left-back Sergio Reguilon slotted in the opener in the first half.
Youssef En-Nesyri converted Lucas Ocampos' cut-back to double the lead just before the break.
A disappointing night for Roma was compounded when Gianluca Mancini was shown a red card in injury time, after a video assistant referee review deemed he had elbowed Luuk de Jong.
Thursday's match was played as a one-off tie in Duisburg, Germany, after the first leg was postponed due to the coronavirus pandemic.
Jules Kounde headed Ever Banega's cross on to the crossbar after 12 minutes as Sevilla made the better start to the first ever competitive meeting between the sides.
Roma were unable to find a second-half response and Sevilla were denied a third when Kounde's finish from Munir's cross was flagged offside, while Banega's injury-time free-kick struck the bar.
Sevilla, unbeaten in 18 in all competitions, have won the competition more than any other side and have gone on to lift the trophy on each of the past three occasions they have reached the quarter-finals.
It was announced earlier on Thursday that US billionaire Dan Friedkin had signed a deal worth 591m euros (£532m) to take over Serie A side Roma.
- 20Santos SilvaBooked at 61mins
- 24JordánBooked at 90mins
- 41Fernández SaezSubstituted forEl Haddadiat 68'minutes
- 51En-NesyriSubstituted forde Jongat 90+3'minutes
- 5OcamposSubstituted forVázquezat 90+6'minutes
- 11El Haddadi
- 19de Jong
- 28Alonso Lara
- 40Pérez Rico
- 23ManciniBooked at 90mins
- 41Ibañez da Silva
- 11KolarovBooked at 45minsSubstituted forVillarat 78'minutes
- 33da Silva Peres
- 42DiawaraSubstituted forPérezat 57'minutes
- 22ZanioloSubstituted forPellegriniat 57'minutesBooked at 86mins
- 19N Kalinic
- Björn Kuipers
- Shots on Target
Second Half ends, Sevilla 2, Roma 0.
Gianluca Mancini (Roma) is shown the red card for violent conduct.
VAR Decision: Card upgraded Gianluca Mancini (Roma).
Luuk de Jong (Sevilla) wins a free kick in the attacking half.
Foul by Gianluca Mancini (Roma).
Offside, Sevilla. Éver Banega tries a through ball, but Franco Vázquez is caught offside.
Attempt saved. Jules Koundé (Sevilla) header from the centre of the box is saved in the centre of the goal. Assisted by Éver Banega with a cross.
Substitution, Sevilla. Franco Vázquez replaces Lucas Ocampos.
Corner, Sevilla. Conceded by Leonardo Spinazzola.
Substitution, Sevilla. Luuk de Jong replaces Youssef En-Nesyri.
Joan Jordán (Sevilla) is shown the yellow card for a bad foul.
Foul by Joan Jordán (Sevilla).
Gonzalo Villar (Roma) wins a free kick in the attacking half.
Attempt saved. Munir El Haddadi (Sevilla) left footed shot from a difficult angle and long range on the right is saved in the top left corner.
Lucas Ocampos (Sevilla) wins a free kick on the right wing.
Foul by Henrikh Mkhitaryan (Roma).
Éver Banega (Sevilla) hits the bar with a right footed shot from outside the box from a direct free kick.
Munir El Haddadi (Sevilla) wins a free kick in the attacking half.
Foul by Carles Pérez (Roma).