Match ends, Wigan Athletic 0, Brentford 3.
Goals from Bryan Mbeumo, Kamohelo Mokotjo and Josh Dasilva lifted Brentford into ninth place in the Championship as they overcame Wigan.
Winger Mbeumo fired the Bees into a fifth-minute lead with his third goal in five games before Mokotjo doubled their advantage midway through the second half.
Any hopes of a Latics comeback were effectively snuffed out soon afterwards when defender Cedric Kipre was shown his second yellow card for bringing down Ollie Watkins.
Dasilva made certain of the points with a late third, rifling home from 25 yards before the Londoners had Julian Jeanvier sent off following a clash with Joe Williams.
Brentford dominated the opening stages and went ahead when Dasilva's corner found Christian Norgaard, who was denied by David Marshall, but the Danish midfielder reacted quickly to tee up Mbeumo from close range.
Joel Valencia and Mokotjo went close to increasing the Bees' advantage, while Wigan offered little aside from Kieffer Moore's 25-yard drive, which zipped just beyond the post.
Former Brentford midfielder Lewis Macleod fired a volley just over early in the second half, but Mokotjo made it 2-0 with a left-footed drive from 15 yards.
Kipre's dismissal four minutes later made it an uphill struggle for the Latics and Dasilva's third goal of the season extended Brentford's advantage.
However, the visitors also finished the game a man short, with Jeanvier red-carded in the aftermath of a scuffle that saw Wigan substitute Joe Gelhardt stretchered off.
Wigan manager Paul Cook:
"It's probably as tough an afternoon as I've had since I came to the club as manager.
"The day just progressively got worse as it went on, and in the end you just couldn't wait for the final whistle. That's about as fair an assessment as I can give."
"We think he (Gelhardt)'s OK, he's gone to hospital with his mum and he was speaking in the ambulance.
"Obviously it was a very heavy knock the kid took, and it just capped a very, very disappointing day for us."
Brentford head coach Thomas Frank told BBC Radio London:
"I think it was another strong away performance and it is very pleasing to win against a very difficult opponent.
"We controlled the game very well and don't think we gave a chance away. We came here with a strong attitude and scored some very good goals.
"Wigan are one of the best teams in this division on offensive set pieces and we kept them very quiet in that part.
"We can see a bit of consistency now with four wins in five and we just need to keep going."
- 15SterlingSubstituted forFoxat 74'minutes
- 21KipreBooked at 73mins
- 20WilliamsBooked at 90mins
- 4MacLeodSubstituted forGelhardtat 63'minutes
- 17JacobsSubstituted forWindassat 63'minutes
- 23JeanvierBooked at 90mins
- 3HenrySubstituted forThompsonat 85'minutes
- 6NørgaardBooked at 58mins
- 19MbeumoSubstituted forJensenat 77'minutes
- 16Valencia CastilloSubstituted forZamburekat 61'minutes
- 29Bech Sørensen
- Andy Davies
- Shots on Target
Second Half ends, Wigan Athletic 0, Brentford 3.
Joe Williams (Wigan Athletic) is shown the yellow card.
Julian Jeanvier (Brentford) is shown the red card for violent conduct.
Ollie Watkins (Brentford) wins a free kick in the attacking half.
Foul by Daniel Fox (Wigan Athletic).
Attempt missed. Joe Williams (Wigan Athletic) right footed shot from outside the box is close, but misses to the right from a direct free kick.
Foul by Christian Nørgaard (Brentford).
Joe Gelhardt (Wigan Athletic) wins a free kick in the attacking half.
Josh Dasilva (Brentford) wins a free kick in the defensive half.
Foul by Joe Williams (Wigan Athletic).
Jan Zamburek (Brentford) wins a free kick on the left wing.
Foul by Jamal Lowe (Wigan Athletic).
Substitution, Brentford. Dominic Thompson replaces Rico Henry.
Goal! Wigan Athletic 0, Brentford 3. Josh Dasilva (Brentford) left footed shot from outside the box to the top left corner. Assisted by Kamohelo Mokotjo.
Attempt blocked. Joe Gelhardt (Wigan Athletic) left footed shot from outside the box is blocked.
Foul by Pontus Jansson (Brentford).
Kieffer Moore (Wigan Athletic) wins a free kick in the attacking half.
Substitution, Brentford. Mathias Jensen replaces Bryan Mbeumo.
Offside, Wigan Athletic. Sam Morsy tries a through ball, but Josh Windass is caught offside.