Serie A leaders Juventus dropped points for the first time since September after drawing 1-1 at Lecce.
Paulo Dybala put Maurizio Sarri's side ahead from the penalty spot early in the second half after Miralem Pjanic had been fouled just inside the area.
Marco Mancosu levelled for Lecce six minutes later with a spot-kick of his own after Matthijs de Ligt's handball.
Second-placed Inter Milan missed the chance to replace Juve at the top after they drew 2-2 with Parma.
It is only the second time this season that the Turin club had failed to win a Serie A match - they were held to a 0-0 draw by Fiorentina in September
With Cristiano Ronaldo rested, former Chelsea striker Gonzalo Higuain led the line alongside fellow Argentine Dybala.
Higuain thought he had put Juve ahead early on when he converted Alex Sandro's drilled cross, but the goal was ruled out for offside following a VAR check.
The 31-year-old, making his 200th Serie A appearance and 100th outing for Juventus, then drilled wide from Dybala's searching pass.
After either side had converted penalties at the start of the second period, Fede Bernardeschi should have restored Juventus' lead when he was sent clean through on goal, but he could only hit the post.
In a frantic finale, Higuain drew a smart stop from Lecce goalkeeper Gabriel as Juventus pushed in vain for a late winner.
Lecce celebrated the draw at the final whistle, with the point moving them up one place to 16th in the table.