- Follow the action from the New Den live
- What to look out for in the FA Cup quarter-finals
- Millwall end four-game losing streak by beating Birmingham City
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: Can the Lions roar again? They have devoured the last five top-flight teams who've dared to tip-toe into their Den.
They've won 31 FA Cup games since 2004 - the fifth best record in the country. It's their 11th quarter-final while outside the top flight. Only Southampton can better that.
But Brighton are a different proposition to the Premier peacocks who've preened there and been picked off.
Their players were in the Championship just two years ago. They know what it takes to win at Millwall. It is over 11 years since they lost there. They are hungry.
Despite crucial recent wins in their relegation battles both have league concerns, but Brighton can more comfortably pick their strongest side ahead of the international break.
Millwall will be without key players injured, suspended and cup-tied. That could prove the difference.
VIEW FROM THE DUGOUT
Millwall manager Neil Harris: "The Den will be rocking at the weekend, even more so now on the back of [Wednesday's win at Birmingham), everyone will be more vibrant and positive.
"Brighton have experienced players and certainly a top manager. They'll come to want to beat us, but we'll enjoy it and what I do know is my players will have a right go because they want to be in the semi-final."
Brighton & Hove Albion manager Chris Hughton: "I went to see [Millwall] on Wednesday - they're a good and physical side.
"We'll start as favourites, but they're the home team on the back of a scalp in the previous round.
"I don't see this game as being any easier than last weekend [against Crystal Palace]."
Millwall have had a great cup run and they will be full of belief after the way they beat another top-flight team, Everton, in round four.
I think this is the wrong time for them to play Brighton, because Chris Hughton's side have got some form back and they will know they are a game away from Wembley.
But I have got a feeling this one will go the distance and I would not be surprised if it is decided on penalties.
Prediction: 1-1 (Brighton to win on penalties)
- Millwall won 3-1 in the only previous FA Cup tie between these sides, a first-round replay on 19 November 1956. The sides had drawn 1-1 at Brighton's Goldstone Ground two days earlier.
- The last eight games, all in the Championship, have produced five draws, two Brighton wins and one Millwall victory.
- The Seagulls are unbeaten in their last six games at the Den (D3, L3) since a 3-0 loss on Boxing Day 2007.
- They have reached their third FA Cup quarter-final in seven years - more than any other side from outside the Premier League in that time.
- All 11 of Millwall's FA Cup quarter-final appearances have come while outside the top flight; only Southampton (13 appearances) have reached this stage more often as a league side.
- The Lions have won their last five FA Cup home matches against top-flight opposition, beating Aston Villa, Bournemouth, Watford, Leicester and Everton.
- The Londoners have lost just one of their last 15 home games in this competition (W11, D3).
- They have not beaten a top-flight side at this stage since eliminating Manchester City in 1937.
Brighton & Hove Albion
- They are in the last eight for the second successive season but only the fourth time in their history.
- Brighton's solitary win at this stage came against Norwich on 12 March 1983, when Jimmy Case scored the only goal at the Goldstone Ground.
- Their other quarter-finals ended in 2-0 defeats - at home to Southampton in 1986 and away to Manchester United last season.
- The Seagulls have won eight of their previous nine FA Cup ties as a top-flight club against lower league opposition, with the only defeat coming against third-tier Oxford United in 1982.
- Anthony Knockaert has two goals and two assists in his last five FA Cup appearances.