Aaron Ramsey out for Wales against Republic of Ireland due to 'family reasons'

Aaron Ramsey in action for Wales
Aaron Ramsey scored for Wales in their 4-1 Uefa Nations League opener against Republic of Ireland in September
Uefa Nations League: Republic of Ireland v Wales
Venue: Aviva Stadium, Dublin Date: Tuesday, 16 October Kick-off: 19:45 BST
Coverage: Live on BBC Radio 5 live, Radio Wales and Radio Cymru, the BBC Sport website and BBC Sport app, plus live text commentary. Highlights on Match of the Day Wales, BBC Two Wales, at 23:10 BST.

Aaron Ramsey is to miss Wales' Uefa Nations League game against the Republic of Ireland.

The 27-year-old Arsenal midfielder is absent attending his partner who has given birth to twins.

Swansea City's Daniel James has been called up for Tuesday's game in Dublin and left the Wales Under-21s squad.

The loss of Ramsey is another blow for Wales manager Ryan Giggs after forward Gareth Bale returned to Real Madrid and Thursday's 4-1 defeat by Spain.

Defender Ben Davies has backed David Brooks to fill the void left by Bale.

Giggs must now also decide on cover for Ramsey, who played the full 90 minutes in the friendly with Spain.

Wales are also without the versatile Ethan Ampadu and defender Chris Mepham while Giggs earlier called up Gwion Edwards and Kieron Freeman as cover.

So far in Group B4, Giggs' side lost 2-0 to Denmark in September after beating the Republic, who drew with the Danes on Saturday.

Bristol City midfielder Callum O'Dowda is a fitness doubt to face Wales, with Republic manager Martin O'Neill adding Portsmouth striker Ronan Curtis to his squad.