Match ends, Manchester United 0, Tottenham Hotspur 3.
Tottenham maintained their 100% start to the Premier League season and increased the pressure on beleaguered Manchester United manager Jose Mourinho with an emphatic victory at Old Trafford.
Mourinho was hoping United would bounce back from an abysmal display in defeat at Brighton, but Spurs ran out easy winners once Harry Kane and Lucas Moura struck twice in the space of two minutes early in the second half.
United were left to rue Romelu Lukaku's missed chance when he rounded Spurs keeper Hugo Lloris from Danny Rose's backpass, but they ended well beaten to make this their worst start to a league season since 1992-93.
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Spurs were simply too good for United after the break and the contest was effectively over once Kane directed in a superb header for his first goal at Old Trafford after 50 minutes and Moura swiftly swept home Christian Eriksen's perfect pass for the second.
The outstanding Moura raced clear to add the third six minutes from time to make it nine points from nine for Spurs.
Mourinho was a dejected figure amid a sea of empty red seats at the final whistle, having lost two of his opening three Premier League games for the first time in his career.
Counterpart Mauricio Pochettino, in contrast, was able celebrate his first victory as Spurs manager at Old Trafford after four straight losses without scoring a goal.
A chastening, miserable night for Mourinho
United are only three games into the new season so it is very early for alarm bells to be ringing, but there is no escaping the fact this has been a dismal start and this side Mourinho has assembled so expensively looks in no shape to challenge for the title.
The manner - as well as the margin - of this loss only increases the feeling of discontent around Old Trafford since the summer.
Mourinho will feel increasing heat but he can rightly point to the pivotal moment when, with United on top, Lukaku missed that simple chance.
There was no lack of effort from United's players but there was an element of collapse to their efforts after Spurs struck twice so quickly.
But this is currently a disjointed team, with Mourinho appearing to be scrambling to find a solution to the very obvious problems he faces in central defence.
He utilised midfielder Ander Herrera in a three-man central defensive system alongside the old guard of Phil Jones and Chris Smalling - with Eric Bailly and Victor Lindelof paying the price for lamentable performances in the loss at Brighton.
It was obvious why Mourinho was desperate to add central defensive reinforcements, but he was also responsible for the acquisition of Bailly and Lindelof at a cost of more than £60m.
He will also be concerned at the complete lack of a response from his players once Spurs delivered that devastating one-two that effectively settled this game in their favour.
This was a chastening, miserable night for United and their manager.
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Landmark win for Spurs?
Mourinho's troubles at United will rightly be the subject of so much attention, but this was a magnificent night for Spurs, who looked a force to be reckoned with.
Their players and supporters celebrated this superb victory in the manner that befitted what might just be a landmark night for Pochettino's team.
It has been a charge regularly levelled at Spurs that they struggle to win games away at their closest title rivals. They put that right in the most emphatic manner possible.
Before this victory, Spurs had won only one of 12 league games against the so-called 'big six' since beating Manchester City in February 2016, so this result will surely do wonders for their self-belief as they attempt to take the next step in their search for silverware.
Once they got into their stride, they simply accelerated away from United.
Kane's magnificent header established the platform, while the pace of Moura - fed brilliantly by Christian Eriksen for his first goal - simply carried too much pace for a leaden-footed United defence.
Spurs, after a slow start, grew in authority, and how did Mourinho and United feel when they saw Toby Alderweireld's powerful defensive display with contributions of importance throughout? He was linked with United this summer but did not arrive.
In fact, when Alderweireld made a superb sliding challenge in the second half, some United fans turned towards executive vice-chairman Ed Woodward in the directors' box to make their feelings known.
For all the talk of Mourinho and missed transfer targets, it is worth remembering Pochettino did not buy any players this summer and can now reflect on three wins from three games this season.
Man of the match - Lucas Moura (Tottenham)
'I don't consider it a difficult time' - what they said
Manchester United manager Jose Mourinho told BBC Sport: "The fans are the best judges in football and they were fantastic to the players.
"I wanted to make sure the fans had from us what they deserve and wanted to be fair to them because they were fantastic. I don't consider it a difficult time.
"[We were] the best team, the offensive team, the team that pressed hard, that created chances and missed chances, but then from the first corner that Tottenham had they scored one goal and immediately that team was in the game.
"I'm frustrated but I'm happy with the players and the performance. We created more chances today than in the majority of our matches.
"What I was trying to do was to keep their motivation and that's not easy. Normally when you play well you win it, and that's what I try not to let go away with the score. One goal comes and everything can change."
On the United defence: "We worked amazingly well this week but there are things that you can't resolve."
Tottenham manager Mauricio Pochettino told BBC Sport: "It is a massive victory for us and I am very proud of the performance.
"It is difficult to beat Manchester United at Old Trafford. They were better in the first half but we dominated from then on, and the clean sheet was a bonus.
"It is only the start of the season and we need to be consistent. We need to be realistic but want to keep pushing and building our fitness. A lot of our players have only had three weeks training but we want to build something special."
Mourinho's biggest home defeat - the stats
- Tottenham have begun a top-flight season with three wins from three games for only the fifth time in history, and the first since 2009-10.
- Manchester United have lost two of their opening three Premier League games for the first time since 1992-93, when they ended up winning the title in the competition's inaugural season.
- This was United boss Jose Mourinho's biggest home defeat in all competitions as a manager.
- Mourinho has lost two of his opening three games in a league season for the first time in his career.
- All three of Tottenham's league wins at Old Trafford have come with a different manager at the helm - Andre Villas-Boas (Sep 2012), Tim Sherwood (Jan 2014) and Mauricio Pochettino.
- This was United's 50th home defeat in the Premier League.
- Tottenham striker Harry Kane has scored at 25 of the 28 Premier League grounds he has played at, the exceptions being Upton Park, the Stadium of Light and Cardiff City Stadium.
- There were just 133 seconds between Tottenham's opening two goals - the quickest time between two goals for the away side at Old Trafford since April 2012 (112 seconds between Nikica Jelavic and Steven Pienaar strikes for Everton).
United travel to Turf Moor to play Burnley and Tottenham face Watford at Vicarage Road, with both games on Sunday 2 September (16:00 BST).
- 1de Gea
- 21HerreraBooked at 19minsSubstituted forSánchezat 55'minutes
- 4JonesSubstituted forLindelöfat 58'minutes
- 25A ValenciaBooked at 58mins
- 31MaticSubstituted forFellainiat 61'minutes
- 2TrippierSubstituted forAurierat 76'minutes
- 3RoseBooked at 77minsSubstituted forDaviesat 82'minutes
- 10KaneBooked at 24minsSubstituted forWinksat 89'minutes
- 27Lucas MouraBooked at 10mins
- 6D Sánchez
- Craig Pawson
- Shots on Target
Second Half ends, Manchester United 0, Tottenham Hotspur 3.
Antonio Valencia (Manchester United) wins a free kick on the right wing.
Foul by Dele Alli (Tottenham Hotspur).
Attempt saved. Alexis Sánchez (Manchester United) right footed shot from outside the box is saved in the top centre of the goal.
Marouane Fellaini (Manchester United) wins a free kick in the attacking half.
Foul by Serge Aurier (Tottenham Hotspur).
Substitution, Tottenham Hotspur. Harry Winks replaces Harry Kane.
Attempt saved. Jesse Lingard (Manchester United) right footed shot from outside the box is saved in the bottom left corner. Assisted by Luke Shaw.
Attempt missed. Fred (Manchester United) header from the centre of the box misses to the left. Assisted by Antonio Valencia with a cross.
Foul by Luke Shaw (Manchester United).
Serge Aurier (Tottenham Hotspur) wins a free kick in the defensive half.
Goal! Manchester United 0, Tottenham Hotspur 3. Lucas Moura (Tottenham Hotspur) right footed shot from the centre of the box to the bottom left corner. Assisted by Harry Kane following a fast break.
Jesse Lingard (Manchester United) wins a free kick in the defensive half.
Foul by Mousa Dembélé (Tottenham Hotspur).
Attempt missed. Christian Eriksen (Tottenham Hotspur) right footed shot from outside the box is too high.
Substitution, Tottenham Hotspur. Ben Davies replaces Danny Rose because of an injury.
Delay over. They are ready to continue.
Delay in match Danny Rose (Tottenham Hotspur) because of an injury.
Attempt missed. Alexis Sánchez (Manchester United) right footed shot from the centre of the box is too high. Assisted by Antonio Valencia with a cross.