Zamalek president Mortada Mansour has sacked coach Ehab Galal after three straight league losses for the Egyptian club.
Galal was Zamalek's 23rd head coach since Mansour became club president in April 2014.
The latest loss for Zamalek was a 2-1 defeat at the hands of visiting Al Ittihad.
Before the league losses Zamalek were also knocked out of the Confederation Cup by Ethiopia's Welayta Dicha.
Galal has been replaced by his namesake Khaled Galal, who will be in charge while the club looks to hire a foreign coach.
Zamalek currently third in the Egyptian league but they are 25 points behind leaders and archrivals Al Ahly, who have a game in hand as well.