Match ends, Spain 6, Argentina 1.
Isco scored a hat-trick as Spain warmed up for the 2018 World Cup by crushing 2014 finalists Argentina in Madrid.
Spain raced into a 2-0 lead when Diego Costa stabbed past Sergio Romero before Isco side-footed his first goal.
Argentina, without injured forward Lionel Messi, pulled it back to 2-1 through Nicolas Otamendi's header.
Isco and Thiago Alcantara extended the lead to 4-1, with substitute Iago Aspas adding the fifth before Isco completed his hat-trick.
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Razor-sharp Spain look real threat
Spain, the 2010 World Cup winners, are now unbeaten in 18 games since Julen Lopetegui took charge following their exit at the first knockout stage of Euro 2016.
They have two more friendlies, against Switzerland and Tunisia, before they launch their World Cup group campaign against European champions Portugal on 15 June.
Lopetegui's side look a major threat on this evidence as they scored with all six shots on target.
Barcelona defender Gerard Pique, who supported the recent Catalan independence referendum, ignored jeers each time he touched the ball in Madrid's Wanda Metropolitano to produce a solid performance at the back.
Andres Iniesta was outstanding in midfield, Isco showed his threat in front of goal as he became the first player since 2013 to score a hat-trick for Spain, and Aspas also did enough to suggest he should make the plane to Russia.
Problems pile up for Argentina
Argentina only secured a place at the World Cup on the final day of South American qualifying, a Messi hat-trick against Ecuador ensuring his country avoided missing a finals for the first time since 1970.
Messi watched this humiliating defeat from the stand as he sat out his second game inside a week after receiving treatment for a muscle injury.
Argentina boss Jorge Sampaoli has work to do to sort out a defence that was cut apart time and again in Spain's capital.
The two-time world champions were vulnerable to counter-attacks, and Chelsea goalkeeper Willy Caballero, a replacement for Manchester United's Romero who was hurt trying to stop Costa's goal, failed to inspire on his second appearance for his country.
Gonzalo Higuain was disappointing in front of goal as Otamendi proved Argentina's biggest threat from set-pieces.
Argentina were also fortunate to finish with 11 men on the pitch as tempers boiled over near the end, prompting Premier League referee Anthony Taylor to blow the whistle on 90 minutes without any time added on.
- 1de Gea
- 3PiquéSubstituted forAzpilicuetaat 72'minutes
- 15RamosBooked at 89mins
- 18AlbaSubstituted forAlonsoat 79'minutes
- 10Thiago AlcántaraSubstituted forParejoat 82'minutes
- 6IniestaSubstituted forSaúlat 56'minutes
- 22IscoBooked at 68minsSubstituted forVázquezat 76'minutes
- 19Diego CostaSubstituted forIago Aspasat 45'minutes
- 17Iago Aspas
- 1RomeroSubstituted forCaballeroat 22'minutes
- 26BustosSubstituted forMercadoat 62'minutes
- 16RojoBooked at 87mins
- 3TagliaficoBooked at 68mins
- 14MascheranoSubstituted forPavónat 56'minutesBooked at 89mins
- 20Lo CelsoSubstituted forAcuñaat 84'minutes
- 19BanegaSubstituted forPérezat 62'minutes
- 27MezaBooked at 81mins
- 9HiguaínSubstituted forMartínezat 59'minutes
- 13Funes Mori
- Anthony Taylor
- Shots on Target
Second Half ends, Spain 6, Argentina 1.
Foul by Iago Aspas (Spain).
Nicolás Tagliafico (Argentina) wins a free kick in the defensive half.
Sergio Ramos (Spain) is shown the yellow card.
Cristian Pavón (Argentina) is shown the yellow card for a bad foul.
Koke (Spain) wins a free kick in the defensive half.
Foul by Cristian Pavón (Argentina).
Attempt blocked. Gabriel Mercado (Argentina) right footed shot from outside the box is blocked. Assisted by Pablo Pérez.
Delay over. They are ready to continue.
Delay in match Marco Asensio (Spain) because of an injury.
Marcos Rojo (Argentina) is shown the yellow card for a bad foul.
Marco Asensio (Spain) wins a free kick in the defensive half.
Foul by Marcos Rojo (Argentina).
Attempt blocked. Marcos Acuña (Argentina) left footed shot from outside the box is blocked.
Foul by Sergio Ramos (Spain).
Lautaro Martínez (Argentina) wins a free kick in the attacking half.
Foul by Koke (Spain).
Maximiliano Meza (Argentina) wins a free kick in the attacking half.
Corner, Argentina. Conceded by Lucas Vázquez.