Gareth Bale continued his comeback from injury with the opening goal as Real Madrid recorded an eventually comfortable first-leg Copa del Rey win at Numancia.
Bale hadn't scored in Spain since September but hit a first-half penalty for his fifth goal of the season.
Numancia, fifth in Spain's second division, had Pape Maly Diamanka sent-off on the hour mark.
Isco then scored another penalty and Borja Mayoral headed in a late third.
Bale has been restricted to just six appearances in La Liga this season because of injuries.
Real will look to secure a quarter-final place next Wednesday, but holders Barcelona were held to a 1-1 draw by Celta Vigo.
- 17MedinaBooked at 82mins
- 5Calvo Sanromán
- 16GutiérrezBooked at 88mins
- 3RipaSubstituted forValcarce Vidalat 20'minutesSubstituted forMateuat 45'minutesBooked at 88mins
- 18SierraSubstituted forPérezat 63'minutes
- 22LarreaBooked at 38mins
- 23Nieto Vela
- 24DiamankaBooked at 60mins
- 9MarínBooked at 51mins
- 7Del Moral Fernandez
- 11Sánchez Romo
- 13Fernández Abarisketa
- 14Valcarce Vidal
- 3VallejoBooked at 59mins
- 24CeballosSubstituted forIscoat 74'minutes
- 20AsensioSubstituted forHakimiat 85'minutes
- 11BaleSubstituted forKovacicat 61'minutesBooked at 90mins
- Javier Estrada Fernández
- Shots on Target