Hull City will be without Abel Hernandez for up to six months after the striker ruptured his Achilles in Tuesday's 3-2 defeat by Wolves.
Uruguay international Hernandez, who had scored three goals in as many games for the Tigers this season, requires surgery to repair the ligament damage.
The 27-year-old was Hull's £10m record signing when he joined in 2014.
"Abel is one of the best forwards in the Championship," boss Leonid Slutsky told the club website.
"It is also a big blow for Abel himself because he had made a very good start to the season and was playing very well for the team."
Slutsky had made a bid for Cardiff striker Kenneth Zohore to fill the void, but the offer was rejected by their Championship rivals.