Match ends, Bayer 04 Leverkusen 2, Atlético de Madrid 4.
Atletico Madrid scored four away goals to take charge of their Champions League last-16 tie against Bayer Leverkusen.
Saul Niguez gave the visitors the lead with a stunning strike, picking the ball up on the right before cutting inside and curling a left-footed shot into the top corner.
Antoine Griezmann doubled their advantage from Kevin Gameiro's pass after woeful defending by Leverkusen skipper Omer Toprak.
Wendell struck his own crossbar in clearing Felipe Luis' cross and home goalkeeper Bernd Leno twice saved well from Griezmann as Leverkusen were fortunate to go in at the break just two goals behind.
Karim Bellarabi pulled one back for Leverkusen early in the second half by finishing off a slick team move, but Gameiro's penalty restored Atletico's two-goal advantage before Stefan Savic's own goal reduced arrears once again.
Substitute Fernando Torres further strengthened Atletico's grip on the tie when he nodded in a late fourth.
The return leg takes place at the Vicente Calderon on Wednesday, 15 March.
Another quarter-final for Atletico?
Diego Simeone's Atletico have real Champions League pedigree, finishing as runners-up both last season and in 2014, and reaching the quarter-finals in between.
The La Liga side dominated the first half at the BayArena and would have been out of sight but for Leno's crucial saves from Griezmann.
On both occasions Leverkusen were totally exposed at the back, but the France international's low strikes were kept out by the legs of the German.
Despite the misses, Griezmann did manage to get on the scoresheet, as did former Liverpool and Chelsea striker Torres, who came off the bench to notch his 41st goal in European competitions.
Much to learn for Leverkusen
Leverkusen finished third in the Bundesliga last season but are struggling this term, 20 points behind leaders Bayern Munich.
They did, however, emerge through the Champions League group stages unbeaten.
Manager Roger Schmidt fielded 17-year-old midfielder Kai Havertz for his first Champions League start, making him the first player born after the 1999 final to start in the competition.
Despite three assists in his last five games, Havertz struggled to make an impression but 20-year-old team-mate Julian Brandt did show his promise with some impressive runs.
Slovenia international Kevin Kampl came close to netting for the hosts in the opening period, but his curled effort was kept out well by Miguel Angel Moya.
Bellarabi's first-time finish early in the second half from Benjamin Henrich's cutback gave the 2002 runners-up hope, while their second goal arrived when Moya spilled a cross onto team-mate Savic's leg and into his own net.
On another night two goals and 62% possession could have seen Leverkusen emerge with the win, but some self-destructive defending ultimately cost them dear.
Man of the match - Kevin Gameiro (Atletico Madrid)
'We showed passion and fight'
Atletico Madrid boss Diego Simeone: "We could even have won by a higher margin but their goalkeeper pulled off two outstanding saves to deny Griezmann. It is important to have belief when you play away from home, and I thought we had that in abundance.
"We thought before the game that, if we attacked down our left side, we would cause their right-footed defenders problems.
"That is exactly what we did. Leverkusen fought their way back into the game in the second half but overall it is a very satisfying evening for us."
Bayer Leverkusen boss Roger Schmidt: "It is easy to see how Atletico have reached two finals in three years. We knew of their counter-attacking abilities before the game but we ended up shipping two goals in the first half.
"We showed passion and readiness to fight. We had a very good 15 minutes towards the end, where the whole stadium got behind us."
Havertz's follows in Draxler's footsteps - stats
- Antoine Griezmann has scored 11 times for Atletico Madrid since the start of last season's Champions League, six more than any other player for the club.
- Griezmann is the top scoring player for Atletico in Champions League/European Cup with 13 goals, overtaking Luis Aragones (12).
- Atletico scored four goals in an away Champions League match for the first time since September 1996 (4-1 against Widzew Lodz).
- This match ended a run of eight Champions League games unbeaten for Leverkusen (won two, drawn six).
- All five of Saul Niguez's Champions League goals have been the opening goal of those games.
- Gabi provided his first Champions League assist since November 2015 (two against Galatasaray).
- Karim Bellarabi scored his first Champions League goal since March 2012 (7-1 loss to Barcelona).
- Kai Havertz became the youngest starter for Bayer Leverkusen in a Champions League match (17 years, 255 days) and the second youngest German to do so after Julian Draxler.
Both sides are back in league action at the weekend. Leverkusen host Mainz in the Bundesliga on Saturday (kick-off 14:30 GMT), while Atletico face a huge trip to Barcelona on Sunday (kick-off 15:15 GMT).
- 39HenrichsBooked at 15mins
- 6DragovicBooked at 58mins
- 18WendellBooked at 64mins
- 20AránguizBooked at 74mins
- 38BellarabiSubstituted forPohjanpaloat 66'minutes
- 29HavertzSubstituted forVollandat 56'minutes
- 19BrandtSubstituted forBaileyat 87'minutes
- 3Filipe LuísBooked at 90mins
- 14Fernández ArenasBooked at 89mins
- 10CarrascoSubstituted forTorresat 78'minutesBooked at 87mins
- 21GameiroSubstituted forParteyat 71'minutes
- 7GriezmannSubstituted forCorreaat 78'minutes
- 27Caio Henrique
- William Collum
- Shots on Target
Second Half ends, Bayer 04 Leverkusen 2, Atlético de Madrid 4.
Wendell (Bayer 04 Leverkusen) wins a free kick in the defensive half.
Koke (Atlético de Madrid).
Attempt saved. Ángel Correa (Atlético de Madrid) right footed shot from a difficult angle on the right is saved in the centre of the goal. Assisted by Fernando Torres.
Attempt blocked. Leon Bailey (Bayer 04 Leverkusen) left footed shot from outside the box is blocked. Assisted by Kevin Kampl.
Filipe Luis (Atlético de Madrid) is shown the yellow card for a bad foul.
Benjamin Henrichs (Bayer 04 Leverkusen) wins a free kick on the right wing.
Foul by Filipe Luis (Atlético de Madrid).
Attempt blocked. Benjamin Henrichs (Bayer 04 Leverkusen) left footed shot from outside the box is blocked.
Gabi (Atlético de Madrid) is shown the yellow card for a bad foul.
Charles Aránguiz (Bayer 04 Leverkusen) wins a free kick in the attacking half.
Foul by Gabi (Atlético de Madrid).
Fernando Torres (Atlético de Madrid) is shown the yellow card for a bad foul.
Chicharito (Bayer 04 Leverkusen) wins a free kick in the attacking half.
Foul by Fernando Torres (Atlético de Madrid).
Substitution, Bayer 04 Leverkusen. Leon Bailey replaces Julian Brandt.
Goal! Bayer 04 Leverkusen 2, Atlético de Madrid 4. Fernando Torres (Atlético de Madrid) header from the right side of the six yard box to the bottom left corner. Assisted by Sime Vrsaljko with a cross.
Corner, Atlético de Madrid. Conceded by Wendell.
Wendell (Bayer 04 Leverkusen) wins a free kick in the defensive half.