Relegated Blackpool will begin life in League Two with a home match against Exeter City, five years after they were relegated from the Premier League.
Doncaster, who also came down from League One last season, travel to Accrington on Saturday, 6 August.
National League champions Cheltenham host Leyton Orient, while Grimsby mark their return to the Football League with a home game against Morecambe.
Carlisle fans face a 700-mile opening weekend round trip to Portsmouth.
The Cumbrians then host Plymouth Argyle on the second Saturday of the season, a 780-mile round journey for supporters of the Pilgrims.
|EFL fixtures released|
Last season's losing play-off finalists Plymouth begin their campaign at home to Luton.
Crewe, who finished bottom of the third tier, visit Stevenage and fellow relegated side Colchester are away at Hartlepool.
The first meeting between Portsmouth and Blackpool, relegated from the top flight in 2010 and 2011 respectively, comes on Saturday, 27 September at Bloomfield Road.
|Opening weekend fixtures (Saturday, 6 August - 15:00 BST)|
|Accrington Stanley v Doncaster Rovers|
|Blackpool v Exeter City|
|Cambridge United v Barnet|
|Cheltenham Town v Leyton Orient|
|Crawley Town v Wycombe Wanderers|
|Grimsby Town v Morecambe|
|Hartlepool United v Colchester United|
|Newport County v Mansfield Town|
|Plymouth Argyle v Luton Town|
|Portsmouth v Carlisle United|
|Stevenage v Crewe Alexandra|
|Yeovil Town v Notts County|