Match ends, Napoli 2, Inter Milan 1.
Napoli replaced Inter Milan at the top of Serie A after Gonzalo Higuain scored twice to help defeat Roberto Mancini's side, who finished with 10 men.
Argentina forward Higuain opened the scoring after just 64 seconds with a thumping effort before Inter had Yuto Nagatomo sent off for two yellow cards.
Napoli, chasing their first Serie A title since 1990, extended their lead after another fine Higuain finish.
Adem Ljajic made it 2-1 before Stevan Jovetic headed against a post.
In a dramatic finish, Inter were again denied an equaliser when Napoli goalkeeper Pepe Reina deflected a header from Miranda onto the post.
The win sent Napoli, who started the day second, one point clear of Inter at the top of the table after 14 games.
Earlier, Fiorentina missed out on a chance to go top after being held 1-1 away to Sassuolo after Sergio Floccari cancelled out Borja Valero's opener.
Fiorentina are third in the table on 29 points, one behind second-placed Inter.
- 2HysajBooked at 36mins
- 26KoulibalyBooked at 11mins
- 5AllanBooked at 52mins
- 17HamsikSubstituted forLópez Silvaat 80'minutes
- 7CallejónBooked at 84minsSubstituted forMaggioat 87'minutes
- 24InsigneSubstituted forEl Kaddouriat 70'minutes
- 4Adriano Buss
- 19López Silva
- 22Vasconcellos Ferreira
- 77El Kaddouri
- 55NagatomoBooked at 44mins
- 13GuarínBooked at 52minsSubstituted forBiabianyat 62'minutes
- 44PerisicSubstituted forJoveticat 83'minutes
- 9IcardiSubstituted forTellesat 45'minutes
- 5Nunes Jesus
- 6Pires Ribeiro
- Daniele Orsato
- Shots on Target
Second Half ends, Napoli 2, Inter Milan 1.
Attempt saved. Stevan Jovetic (Inter Milan) header from the centre of the box is saved in the bottom left corner. Assisted by Jonathan Biabiany with a cross.
Stevan Jovetic (Inter Milan) hits the right post with a header from the centre of the box. Assisted by Danilo D'Ambrosio with a cross.
Corner, Inter Milan. Conceded by Elseid Hysaj.
Foul by David López (Napoli).
Jeison Murillo (Inter Milan) wins a free kick in the defensive half.
Corner, Napoli. Conceded by Samir Handanovic.
Attempt saved. Gonzalo Higuaín (Napoli) left footed shot from the left side of the box is saved in the bottom right corner. Assisted by David López.
Substitution, Napoli. Christian Maggio replaces José Callejón.
Attempt missed. Marcelo Brozovic (Inter Milan) right footed shot from outside the box misses to the left following a set piece situation.
José Callejón (Napoli) is shown the yellow card for a bad foul.
Foul by José Callejón (Napoli).
Adem Ljajic (Inter Milan) wins a free kick on the left wing.
Substitution, Inter Milan. Stevan Jovetic replaces Ivan Perisic.
Offside, Inter Milan. Alex Telles tries a through ball, but Adem Ljajic is caught offside.
Substitution, Napoli. David López replaces Marek Hamsik.
Attempt missed. Marcelo Brozovic (Inter Milan) right footed shot from outside the box is close, but misses to the right. Assisted by Alex Telles.
Offside, Napoli. Faouzi Ghoulam tries a through ball, but Gonzalo Higuaín is caught offside.
Offside, Inter Milan. Gary Medel tries a through ball, but Adem Ljajic is caught offside.