Gareth Bale is set to return for Real Madrid, giving new hope he will make Wales' Euro 2016 qualifier against Bosnia-Herzegovina on 10 October.
Real visit fierce rivals Atletico Madrid six days earlier in La Liga.
The Spanish club's boss Rafael Benitez hopes Bale, who has been out with a calf problem, and James Rodriguez will recover from injury in time.
"I am very cautious, but they are recovering well," said former Liverpool manager Benitez.
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"We will see how they are once they begin to train with the team next week."
Bale limped out of Real's 4-0 Champions League win over Shakhtar Donetsk on 16 September and a scan later confirmed the injury.
The 26-year-old has scored six of Wales' nine goals to spearhead their bid to reach the finals of a major tournament for the first time since the 1958 World Cup.
After travelling to Zenica to face Bosnia-Herzegovina, they then host Andorra on Tuesday 13 October.
Chris Coleman's side need a point to qualify for the Euro 2016 finals, which will take place in France.