Match ends, Reading 0, MK Dons 0.
Reading remain without a home win in seven games as their first-ever league meeting with MK Dons finished goalless.
Simon Church struck a post for MK Dons against his former club in the first half, after Orlando Sa's header was ruled offside for Reading.
Oliver Norwood and Nick Blackman were denied by Dons keeper David Martin after the interval.
A second goalless draw at home this season for the Royals means they have won just once in 14 league games.
Manager Steve Clarke will wonder how his side failed to score once again in front of their own supporters, after creating the majority of the chances against the Dons, who were promoted last season.
Church's left-foot shot against the foot of the post was the best the visitors could fashion in the opening 45 minutes.
Sa was at the heart of Reading's best efforts and twice saw goal-bound shots blocked in the first half.
Hal Robson-Kanu also brought out a point blank save from Martin after Sa's shot deflected into his path.
Reading midfielder Norwood showed his shooting prowess in both halves but Martin reacted well to parry a first-half effort before pushing behind a low strike after the interval.
The 29-year-old was alert once more to save substitute Blackman's drive and ensure a first away clean sheet of the season for Karl Robinson's Dons.
Reading manager Steve Clarke: "Frustrated isn't the right word. It was another solid performance, no doubt we controlled the game from start to finish.
"We had another 20 attempts at goal, seven or eight of them on target. Every game this season is almost like the carbon copy of the one before.
"But, as I said to the players in the dressing room, if they continue to play like this, the goals will come for sure."
MK Dons manager Karl Robinson told BBC Three Counties Radio: "I thought we really eliminated their chances. I think they showed us tremendous respect and played a system today they've also played away from home.
"We didn't expect them to play that way. It's difficult to play against, but I thought the way the players conducted themselves against it, we've actually come the closest to scoring in the game.
"Tactically, I thought the players got it perfectly well. I thought it was a comfortable draw and they didn't threaten us too much towards the end."
- 18TshibolaBooked at 56minsSubstituted forCoxat 69'minutes
- 21QuinnSubstituted forFernández Iglesiasat 86'minutes
- 9Robson-KanuSubstituted forBlackmanat 69'minutes
- 19Fernández Iglesias
- 26Al Habsi
- 5McFadzeanBooked at 68mins
- 39PoyetBooked at 64mins
- 38HallSubstituted forBakerat 73'minutesBooked at 90mins
- 14CarruthersSubstituted forPowellat 60'minutes
- 11ChurchSubstituted forGallagherat 67'minutes
- David Coote
- Shots on Target
Second Half ends, Reading 0, MK Dons 0.
Attempt missed. Paul McShane (Reading) header from the centre of the box misses to the right. Assisted by Oliver Norwood following a set piece situation.
Carl Baker (MK Dons) is shown the yellow card.
Foul by Carl Baker (MK Dons).
Daniel Williams (Reading) wins a free kick on the left wing.
Jordan Spence (MK Dons) wins a free kick on the right wing.
Foul by Simon Cox (Reading).
Diego Poyet (MK Dons) wins a free kick in the attacking half.
Foul by Nick Blackman (Reading).
Substitution, Reading. Álex Fernández replaces Stephen Quinn.
Attempt missed. Anton Ferdinand (Reading) header from the centre of the box is high and wide to the right. Assisted by Stephen Quinn with a cross following a corner.
Corner, Reading. Conceded by Sam Gallagher.
Foul by Daniel Powell (MK Dons).
Chris Gunter (Reading) wins a free kick on the right wing.
Foul by Dean Lewington (MK Dons).
Nick Blackman (Reading) wins a free kick in the defensive half.
Offside, Reading. Jordan Obita tries a through ball, but Orlando Sá is caught offside.
Foul by Sam Gallagher (MK Dons).
Anton Ferdinand (Reading) wins a free kick in the defensive half.