Manchester United goalkeeper David De Gea dislocated a finger while on international duty with Spain.
The Spanish Football Association confirmed the 24-year-old will miss the Euro 2016 qualifier against Belarus in Huelva on Saturday.
He will be assessed by the Spain team doctors before a decision is made on whether to send him back to his club.
Chelsea midfielder Cesc Fabregas has already been ruled out of the Group C match with a hamstring injury.
"David de Gea was forced to stop training after suffering an injury to the fifth finger of his right hand," read statement on the national team's website.
"Having suffered a similar situation in the past, De Gea will remain with the squad and will wait to see how he improves."