Liverpool striker Daniel Sturridge is facing up to a further month out after suffering a calf strain in training.
Sturridge, 25, had just recovered from a thigh strain sustained on England duty in September.
He has played only three Premier League games this season and may miss the next seven matches, including both Champions League meetings with Real Madrid.
"He's looking at being out for two to four weeks," Liverpool manager Brendan Rodgers told the Liverpool Echo.
"It's a big blow as we were looking forward to welcoming Daniel back. He has worked tirelessly.
"But we have other players training hard and working hard and we will turn to them. It's why we bulked up the squad in the summer."
Sturridge, who scored 25 goals in all competitions last season, was expected to return in Liverpool's Premier League match at QPR on Sunday.
England face Slovenia in a Euro qualifier at Wembley on 15 November, followed by a friendly against Scotland at Celtic Park on 18 November.