Wrexham midfielder Jay Harris could miss up to three games because of a hip problem including Saturday's home game against Woking.
Harris, 27, was forced off during Bank Holiday Monday's home draw against Macclesfield with the injury.
"Jay is a big player and will be a loss," manager Kevin Wilkin said.
Wilkin is already without captain Dean Keates, who has yet to feature this season because of a hamstring problem.
"Any side that loses two midfielders as influential as those two will suffer," Wilkin added.
"Time will tell whether the players we've got and the depth that we've got is where it needs to be.
"People have been chomping at the bit to get in there and take a chance.
"It provides another chance for somebody else and hopefully whoever comes in gets on and does the job and keeps us moving forward."
The Wrexham manager has not ruled out bringing in reinforcements before the transfer window closes on Monday.
But Wilkin admits any new signings will have to made within Wrexham's budget.
"We know there are players out there - it's whether we can fit them in to what we've got to spend," Wilkin said.
"That probably will be the issue but if we do then great, if not we'll get on with what we've got and we'll dip into the loan market further down the line."