Andy Reid, Rob Elliot and Kevin Doyle have withdrawn from the Republic of Ireland squad for Wednesday's friendly against Serbia at the Aviva Stadium.
Nottingham Forest midfielder Reid underwent hernia surgery on Friday and is expected to be ruled out for up to six weeks.
QPR striker Doyle has a thigh injury while Newcastle keeper Elliot has a knee problem.
Republic boss Martin O'Neill has opted not to call up any replacements.
REPUBLIC OF IRELAND SQUAD
Goalkeepers: David Forde (Millwall), Darren Randolph (Birmingham)
Defenders: Richard Keogh (Derby), Marc Wilson (Stoke), Seamus Coleman (Everton), John O'Shea (Sunderland), Alex Pearce (Reading), Stephen Kelly (Reading), Damien Delaney (Crystal Palace), Richard Dunne (QPR), Ciaran Clark (Aston Villa), Stephen Ward (Brighton)
Midfielders: James McCarthy (Everton), Glenn Whelan (Stoke), Paul Green (Ipswich), Aiden McGeady (Everton), Anthony Pilkington (Norwich), James McClean (Wigan), Stephen Quinn (Hull), David Meyler (Hull), Wes Hoolahan (Norwich)
Strikers: Shane Long (Hull), Daryl Murphy (Ipswich), Jon Walters (Stoke), Anthony Stokes (Celtic), Simon Cox (Nottingham Forest)