Match ends, Sunderland 1, Southampton 0.
Sunderland continued their cup success this season as a much-changed side saw off a poor Southampton team to reach the FA Cup quarter-finals.
Gus Poyet's Black Cats have already reached the Capital One Cup final and they were rarely tested as Craig Gardner's fine strike settled the tie.
James Ward-Prowse had a shot saved for the Saints with Rickie Lambert missing an open goal from four yards out.
Sunderland's win came in front of only 16,777 fans at the Stadium of Light.
Lambert's missed opportunity summed up Southampton's afternoon as they failed to capitalise on a potential chance of silverware to add to an impressive Premier League campaign.
They sit eighth in the top flight after enjoying a six-game unbeaten run since the start of the year but Mauricio Pochettino still decided to make alterations to his team.
In contrast, Poyet's side had reason to take this tie less seriously given they are in the Premier League bottom three and face a League Cup final against Manchester City in two weeks' time.
With those targets uppermost in his mind the Uruguayan made nine changes to the side that lost last weekend at home to Hull, but Sunderland still showed greater willingness to press their opponents and support their team-mates in attack.
And in Gardner's 25-yard effort four minutes after the break, the hosts had the game's outstanding moment as they won for the seventh time in their past 10 outings.
Sunderland could have gone ahead in the first half when Fabio Borini appeared to be brought down by Luke Shaw just inside the box but the hosts' vehement penalty appeals went unheeded.
Southampton improved and Ward-Prowse draw a decent save from Black Cats goalkeeper Oscar Ustari after smart build-up play by Adam Lallana and Rickie Lambert.
Overall, the first half lacked any real quality in the final third but that changed soon after the break when Gardner picked up Jos Hooiveld's loose clearance and smashed a shot in off the bar from 25 yards.
Pochettino threw on Rodriguez to try and inspire a response and Lambert should really have equalised from Nathaniel Clyne's low cross before Lallana missed another chance from the same supply line.
But Black Cats substitute Connor Wickham almost touched in Sebastian Larsson's cross and Borini tested Kelvin Davis in Southampton's goal as Sunderland finished the stronger.
Sunderland boss Gus Poyet, after being reminded that former manager Bob Stokoe led the Black Cats to FA Cup glory in 1973 and was commemorated by a statue: "Apparently to be more famous, it's better to win the cup. I don't want any more people knowing me, I think they know me enough, so I would prefer to stay in the Premier League.
"It's a personal feeling. I can't answer for anybody else, it's me. I would be devastated if we go down, so it's me."
Assistant manager Jesus Perez on why Southampton made six changes: "Obviously, it was a tough game against Hull [on Tuesday], we played away as well, we came home late and some of our players were not fully recovered and we decided the best players to play today.
"For us, every single player is important and useful for us and it doesn't matter who is on the pitch.
"There was a lack of freshness, that's obvious, but nothing more."
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- 3DossenaSubstituted forAlonsoat 77'minutes
- 7LarssonBooked at 90mins
- 8GardnerSubstituted forColbackat 83'minutes
- 30ScoccoSubstituted forWickhamat 69'minutes
- 4Ki Sung-yueng
- 3YoshidaBooked at 25mins
- 16Ward-ProwseSubstituted forSchneiderlinat 62'minutes
- 8DavisBooked at 42mins
- 20LallanaSubstituted forMcQueenat 82'minutes
- 21Do PradoSubstituted forRodriguezat 62'minutesBooked at 90mins
- 6José Fonte
- Mike Dean
- Shots on Target
Second Half ends, Sunderland 1, Southampton 0.
Foul by Nathaniel Clyne (Southampton).
Jack Colback (Sunderland) wins a free kick on the left wing.
Corner, Southampton. Conceded by Sebastian Larsson.
Sebastian Larsson (Sunderland) is shown the yellow card.
Attempt blocked. Steven Davis (Southampton) right footed shot from outside the box is blocked. Assisted by Jay Rodriguez.
Corner, Sunderland. Conceded by Steven Davis.
Jay Rodriguez (Southampton) is shown the yellow card.
Corner, Sunderland. Conceded by Victor Wanyama.
Attempt blocked. Connor Wickham (Sunderland) left footed shot from outside the box is blocked. Assisted by Fabio Borini.
Attempt saved. Fabio Borini (Sunderland) right footed shot from the centre of the box is saved in the centre of the goal. Assisted by Jack Colback.
Attempt missed. Luke Shaw (Southampton) left footed shot from the left side of the box misses to the left. Assisted by Victor Wanyama.
Attempt saved. Jos Hooiveld (Southampton) left footed shot from outside the box is saved in the centre of the goal. Assisted by Steven Davis.
Attempt missed. Connor Wickham (Sunderland) left footed shot from the left side of the box misses to the right. Assisted by John O'Shea.
Foul by Victor Wanyama (Southampton).
Fabio Borini (Sunderland) wins a free kick in the defensive half.
Substitution, Sunderland. Jack Colback replaces Craig Gardner.
Substitution, Southampton. Sam McQueen replaces Adam Lallana.
Attempt missed. Rickie Lambert (Southampton) right footed shot from very close range is too high. Assisted by Nathaniel Clyne with a cross.