Marseille have sacked boss Elie Baup after Friday's 1-0 defeat at Nantes.
The 58-year-old led the club to second place in Ligue 1 and a Champions League spot last season but they sit fifth this season.
President Vincent Labrune said that the team were lacking the desire and quality expected this season.
Former Marseille midfielder Joseph Barton said on Twitter: "Very sad for Elie Baup. Good man. Enjoyed my time working with him."
Sporting director Jose Anigo will take charge of the next four games, starting with Wednesday's Champions League game with Borussia Dortmund.
Marseille are bottom of Group F having lost all five games, but Dortmund's qualification is still undecided.
Baup managed Bordeaux, Saint-Etienne, Toulouse and Nantes before becoming Marseille boss in 2012 after the departure of Didier Deschamps.
Marseille have won nine league titles, the last of which came in 2010.