Southport 2-1 Gateshead
Karl Ledsham struck a brace for Southport to condemn Gateshead to their fourth straight defeat of the season.
Ledsham put the home side in front when his header from Paul Rutherford's cross found the bottom corner.
The 25-year-old doubled his side's lead on the stroke of half-time, with his left-foot shot beating Adam Bartlett.
The visitors gave themselves hope when Richard Brodie struck from close range but the hosts hung on to move up to third while Gateshead remain pointless.