Tamworth 2-1 Southport
Darren Byfield scored deep into injury time as Tamworth came from behind to beat 10-man Southport.
Southport made the breakthrough just before half-time when Aaron Chalmers headed home the rebound after Liam Mitchell had saved his penalty.
But Southport keeper Tony McMillan was shown a straight red card for deliberate handball after the break.
Danny Lloyd volleyed home from the edge of the area to equalise, before Byfield rifled in a last-gasp winner.